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Issue Date: 16-Mar-2018
Authors: Sciuto, Emanuele Luigi
Title: Development of Innovative Technologies for DNA Extraction and Detection
Abstract: The Ph.D. project has been focused on the development of fast, multiplex, innovative and easy-to-use technological platforms for DNA analysis (from extraction to detection), implemented into portable and miniaturized devices. These types of technologies are called Point-of-Care (PoC) and could create the conditions for a more efficient clinical analysis, introducing a series of advantages: Fast and cheap procedures for biological samples preparation and analysis Fast diagnosis Identification and analysis of different DNA mutations (complex phenotypes and drug-resistance related) Disease-specific and therapy-specific pattern definition My research activity has been divided into three main parts, which will be described in the subsequent chapters: 1. Development and characterization of a miniaturized platform for DNA extraction. 2. Development and characterization of miniaturized systems for DNA detection with both optical transduction methods (via RT-PCR) and electrical methods (electrochemical detection). 3. Development of molecular methods for the detection of environmental analytes.
Appears in Collections:Area 02 - Scienze fisiche

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