Behaviour disorders dopamine-related

Abstract

Today there is a growing awareness that in Parkinson's disease can occur motor and non motor disorders, in particular substances dependency syndromes and behavioral addiction. Objectives of the study. Objective of the study is to determine any changes frontal circuits potentially involved in the development and maintenance of "behaviour addiction", by neuroimaging and neurophysiological methods in patients with Parkinson's disease with impulses control disorder. Materials and methods. In the study of 8 patients with Parkinson's disease with at least an impulse control disorder, particularly 8 pathological gambler , and 8 patients with non-demented Parkinson disease with comparable clinical and demographic characteristics who had not demonstrated behavioural abnormalities . Patients were subjected to a magnetic resonance imaging with conventional sequences and DWIs in 15 space directions (diffusion tensor imaging) and T1 weighted sequences volumetric, determination of P 300 neurophysiological and neuropsychological test battery for exploring the cognitive functions. Results. The two groups have had no statistically significant differences evaluated using t-Student test, although patients with ICDS have shown average levels of FA tend to higher; in assessing NP the only statistically significant differences have emerged the WCST and NPI. However, it should be pointed out as ICD patients, compared to Parkinsoniani without compulsive disorder, P3a monsters lower latency than the P3b, as evident in healthy subjects.