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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/10761/1322
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Data: | 15-feb-2013 |
Autori: | Caranci, Giovanni |
Titolo: | Plasma alpha synuclein assay in Parkinson's disease and parkinsonisms |
Abstract: | In this observational cross-sectional study, using an immunoenzymatic technique we assayed and compared total plasma alpha-synuclein concentrations in 69 patients with Parkinson's disease and 110 age-matched healthy control subjects. Two previously unreported findings concerned gender. First, plasma alpha-synuclein concentrations measured in the more advanced parkinsonian disease
stages decreased in men but not in women. Second, again only in men, plasma alphasynuclein concentration was associated with cognitive impairments, hallucinations, depressed mood and sleep disorders. These findings underline the gender-related differences in parkinsonian patients and indicate plasma alpha-synuclein expression as a potential biological marker for Parkinson's disease progression in men. |
In | Area 06 - Scienze mediche
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CRNGNN77P14E335P-CARANCI-PhD.pdf | CARANCI-PhD.pdf | 1,8 MB | Adobe PDF | Visualizza/apri
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