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Issue Date: 12-Dec-2017
Authors: Monciino, Giulia
Title: Synthesis and biological evaluation of pirrolidine, oxazolidin-2-imine and mercaptoketones derivates as HCV, HIV and HDAC inhibitors
Abstract: The main objective of this thesis was the synthesis of modified azanucleosides potential ihibitors of non-structural proteins of HCV virus ((NS) NS3/4A, NS4B, NS5A and NS5B). Moreover the research project included the synthesis of pyrimidine-1,3-oxazolidin-2-arylimino hybrids as HIV ihibitors and the synthesis of mercaptoketone deriatives as antitumor agents potential HDAC's inhibitor.
Appears in Collections:Area 06 - Scienze mediche

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